MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke.

@article{Rosell2008MMP9positiveNI,
  title={MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke.},
  author={Anna Perdrix Rosell and Eloy Cuadrado and Arantxa Ortega-Aznar and Mar Hern{\'a}ndez-Guillam{\'o}n and Eng H. Lo and J Montaner},
  journal={Stroke},
  year={2008},
  volume={39 4},
  pages={
          1121-6
        }
}
  • Anna Perdrix Rosell, Eloy Cuadrado, +3 authors J Montaner
  • Published in Stroke 2008
  • Medicine
  • BACKGROUND AND PURPOSE An abnormal expression of some matrix metalloproteinases (MMPs) is related with hemorrhagic transformation events after stroke. Our aim was to investigate MMP-2 and MMP-9 in the ischemic brain and its relation with blood-brain barrier breakdown after hemorrhagic transformation in human stroke. METHODS We assessed 5 cases of fatal ischemic strokes with hemorrhagic complications; brain samples were obtained from infarct, hemorrhagic, and contralateral tissue. MMP-9 and… CONTINUE READING

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