MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model.

@article{Chen2012MMP9IS,
  title={MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model.},
  author={Desheng Chen and Xianlong Zhang and Yongyuan Guo and Sifeng Shi and Xin Mao and Xiaoyun Pan and Tao Cheng},
  journal={International journal of molecular medicine},
  year={2012},
  volume={30 6},
  pages={1417-23}
}
Wear debris-induced osteolysis in periprosthetic tissue with aseptic loosening is a serious problem after total joint arthroplasty. Matrix metalloproteinase-9 (MMP-9) is expressed in osteoclast cells that surround loosening peri-implant tissue, but the molecular mechanism of MMP-9 action in wear debris-induced osteolysis remains ambiguous. We used a murine osteolysis model to examine the hypothesis that administration of an MMP-9 inhibitor reduces the expression of receptor activator of nuclear… CONTINUE READING