MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration.

@article{RedondoMuoz2006MMP9IB,
  title={MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration.},
  author={Javier Redondo-Mu{\~n}oz and Elizabeth Escobar-D{\'i}az and Rafael Samaniego and Mar{\'i}a Jos{\'e} Terol and Jos{\'e} Antonio Garc{\'i}a-Marco and {\'A}ngeles Garc{\'i}a-Pardo},
  journal={Blood},
  year={2006},
  volume={108 9},
  pages={3143-51}
}
B-cell chronic lymphocytic leukemia (B-CLL) progression is determined by malignant cell extravasation and lymphoid tissue infiltration. We have studied the role and regulation of matrix metalloproteinase-9 (MMP-9) in B-CLL cell migration and invasion. Adhesion of B-CLL cells to the fibronectin fragment FN-H89, VCAM-1, or TNF-alpha-activated human umbilical vein endothelial cells (HUVECs) up-regulated MMP-9 production, measured by gelatin zymography. This effect was mediated by alpha4beta1… CONTINUE READING

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