MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier.

@article{Bonoiu2009MMP9GS,
  title={MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier.},
  author={Adela C Bonoiu and Supriya D. Mahajan and Ling Ye and Rajiv Kumar and Hong Ding and Ken-Tye Yong and Indrajit Roy and Ravikumar Aalinkeel and Bindukumar B. Nair and Jessica L. Reynolds and Donald E. Sykes and Marco A Imperiale and Earl J. Bergey and Stanley A. Schwartz and Paras N Prasad},
  journal={Brain research},
  year={2009},
  volume={1282},
  pages={142-55}
}
The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, are involved in the neuroinflammation processes leading to disrupting of the blood brain barrier (BBB), thereby exacerbating neurological diseases such as HIV-1 AIDS dementia and cerebral ischemia. Nanoparticles have been proposed to act as non-viral gene delivery vectors and have great potential for therapeutic applications in several disease states. In this study, we evaluated the specificity and efficiency of quantum dot (QD… CONTINUE READING

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