MMP-9 gene ablation mitigates hyperhomocystenemia-induced cognition and hearing dysfunction

Abstract

Hyperhomocysteinemia (HHcy) is associated with cognitive decline and hearing loss due to vascular dysfunction. Although we have shown that HHcy-induced increased expression of matrix metalloproteinase-9 (MMP-9) is associated with cochlear pathology in cystathionine-β-synthase heterozygous (CBS+/−) mice, it is still unclear whether MMP-9 contributes to… (More)
DOI: 10.1007/s11033-014-3425-x

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