MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.

  title={MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.},
  author={Conor C. Lynch and Atsuya Hikosaka and Heath B Acuff and Michelle E. D. Martin and Noriyasu Kawai and Rakesh K. Singh and Tracy C Vargo-Gogola and Jennifer L Begtrup and Todd E. Peterson and Barbara Fingleton and Tomoyuki Shirai and Lynn M Matrisian and Mitsuru Futakuchi},
  journal={Cancer cell},
  volume={7 5},
We developed a rodent model that mimics the osteoblastic and osteolytic changes associated with human metastatic prostate cancer. Microarray analysis identified MMP-7, cathepsin-K, and apolipoprotein D as being upregulated at the tumor-bone interface. MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation. MMP-7-deficient mice demonstrated reduced prostate tumor-induced osteolysis and RANKL… CONTINUE READING

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