MMP-7 inhibits CTL – tumor cell interaction

Abstract

In a cleavage assay with recombinant CD95 protein, we could show that MMP-7, cleaved approximately 2–3 kDa from the extracellular N-terminal end of CD95. In coculture experiments with 51Cr-labeled HepG2-cells, we found a significant decrease of cytotoxic action of peptide specific CTLs in the presence of MMP-7. In addition MMP7 leads to a higher adhesion of… (More)
DOI: 10.1186/1475-2867-4-S1-S6

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