MMP-28 as a regulator of myelination

  title={MMP-28 as a regulator of myelination},
  author={Sean R Werner and Joseph E Dotzlaf and Rosamund C. Smith},
  journal={BMC Neuroscience},
  pages={83 - 83}
Matrix metalloproteinase-28 (MMP-28) is a poorly understood member of the matrix metalloproteinase family. Metalloproteinases are important mediators in the development of the nervous system and can contribute to the maturation of the neural micro-environment. MMP-28 added to myelinating rat dorsal root ganglion (DRG) co-cultures reduces myelination and two antibodies targeted to MMP-28 (pAb180 and pAb183) are capable of binding MMP-28 and inhibiting its activity in a dose-dependent manner… CONTINUE READING


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