MMP(-2) expression in skeletal muscle after strength training.


The aim of this study was to assess the effects of resistance training on ladders (RTL) on MMP(-2) expression and blood lactate concentration [La-]. 30 male (3 months of age), albino rats were divided into 3 groups: sedentary control (SC, n=10), low resistance exercise training (Low-IntRT, n=10) and high-intensive exercise training (High-IntRT, n=10). Animals of High-IntRT were submitted to a progressively increasing overload in relation to body weight until exhaustion, while the Low-IntRT group performed the same exercise regimen with no external load. The program had a frequency of 3 times per week over 8 weeks. MMP(-2) expression of tibialis anterior muscle and [La-] were measured. While there was a significant increase of MMP(-2) (pro-form) in both groups, only High-IntRT significantly increased MMP(-2) in active-form (p<0.05). Both trained groups exhibited an increase in [La-] when compared to controls, however, the increase in [La-] was significantly higher in the High-IntRT compared to Low-IntRT (p<0.05). Strong correlation was found between MMP(-2) (active form) and [La-] in High-IntRT (r=0.91). RTL in using low and high-intensity exercise can serve as a model to demonstrate different responses of MMP(-2) expression in an animal model. It appears active form expression of MMP(-2) is modulated by exercise intensity.

DOI: 10.1055/s-0031-1291224

Cite this paper

@article{Deus2012MMP2EI, title={MMP(-2) expression in skeletal muscle after strength training.}, author={Antonio L. Deus and Deepa Bassi and R P Sim{\~o}es and Catarina Oliveira and Vilmar Baldissera and Rita de C{\'a}ssia Marqueti and Heloisa Sobreiro Selistre de Ara{\'u}jo and Ross Arena and Audrey Borghi-Silva}, journal={International journal of sports medicine}, year={2012}, volume={33 2}, pages={137-41} }