MMP-2 Assessment as an Indicator of Wound Healing: A Feasibility Study

@article{Karim2006MMP2AA,
  title={MMP-2 Assessment as an Indicator of Wound Healing: A Feasibility Study},
  author={Refaat B. Karim and Beatriz L R Brito and Richard P. Dutrieux and Fernanda P Lassance and J. Joris Hage},
  journal={Advances in Skin \& Wound Care},
  year={2006},
  volume={19},
  pages={324-327}
}
OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, ≥ 3 months; surface area, ≥ 1 cm2). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing. RESULTS… 
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27 Citations
Background Citations
6
Methods Citations
1
Results Citations
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27 Citations

Citation Type

Citation Type

Efficacy of MMP-inhibiting wound dressings in the treatment of hard-to-heal wounds: a systematic review.
TLDR
Evidence for the superiority of some MMP-inhibiting wound dressings exists regarding wound closure, wound size reduction, healing time and healing rate.
REZUMAT PROTEASES AS BIOMARKERS IN WOUND HEALING
TLDR
The main aim of the study was to explore the literature that refers on proteases role as biomarkers in predicting wound healing progress and establish the relevance of this knowledge for practice area.
Effect of low-level laser therapy on angiogenesis and matrix metalloproteinase-2 immunoexpression in wound repair
TLDR
Low-level laser therapy improves wound healing by enhancing neocollagenesis, increasing the amount of new vessels formed in the tissue (neoangiogenesis), and modulating MMP-2 expression.
Chronic wound diagnostic for matrix metalloproteinase
TLDR
A prototype device is developed that can be used by wound care providers at the point-of-care to rapidly measure MMP activity in swab samples of wound fluid to provide critical information on the healing trajectory of the wound and if the wound bed is adequately prepared for advanced biological therapies.
EFFECT OF THE ENZYME-CONTAINING POLYMERIC NANOPARTICLES ON MMP-2 ACTIVITY DURING BURN WOUND HEALING IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES
TLDR
The use of enzyme-containing nanoparticles provides effective degradation of glycosylated components of the extracellular matrix (AGEs), thereby reducing the inflammatory process and activity of MMP-2, and promoting wound healing in rats with streptozotocin-induced diabetes.
Morphine enhances tissue content of collagen and increases wound tensile strength
TLDR
It is demonstrated that systemic administration of morphine enhances tissue collagen deposition in the cutaneous tissue, thereby increasing the tensile strength of the incisional wound.
Acute and chronic wound fluids influence keratinocyte function differently
TLDR
Keratinocyte migration was significantly impaired byCWF in contrast to an undisturbed wound closure under the influence of AWF, and MMP‐9 expression was strongly upregulated by CWF compared with AWF.
Biology and Biomarkers for Wound Healing
TLDR
A focus on simplicity and consistent implementation of these biomarkers, as well as an emphasis on efficacious follow-up therapeutics, is necessary for transition of this technology to clinically feasible point-of-care applications.
Protease activity as a prognostic factor for wound healing in venous leg ulcers.
TLDR
This review identified very low validity evidence regarding any association between protease activity and VLU healing and concluded there is complete uncertainty as to the relationship research and future research.
Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases
TLDR
MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6 and the etiology of these changes in unclear, trauma and wound healing likely play a role.
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