MMP-2 (-1306 C/T) Polymorphism Affects Serum Matrix Metalloproteinase (MMP)-2 Levels and Correlates with Chronic Obstructive Pulmonary Disease Severity: A Case–Control Study of MMP-1 and -2 in a Tunisian Population

Abstract

The aim of this study was to determine the role of MMP-1 (-1607 1G/2G; -519 A/G) and MMP-2 (-1306 C/T; -735 C/T) polymorphisms in the development and severity of chronic obstructive pulmonary disease (COPD) in Tunisian patients. We also evaluated the impact of these genetic variants on serum levels of the corresponding proteins. The study included 138… (More)
DOI: 10.1007/s40291-016-0225-0

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@article{Bchir2016MMP2C, title={MMP-2 (-1306 C/T) Polymorphism Affects Serum Matrix Metalloproteinase (MMP)-2 Levels and Correlates with Chronic Obstructive Pulmonary Disease Severity: A Case–Control Study of MMP-1 and -2 in a Tunisian Population}, author={Sarra Bchir and Hela ben Nasr and Amel ben Anes and Mohamed Benzarti and Abdelhamid Garrouch and Zouhair Tabka and Karim Chahed}, journal={Molecular Diagnosis & Therapy}, year={2016}, volume={20}, pages={579-590} }