MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis.

@article{Ulrich2006MMP12MA,
  title={MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis.},
  author={Reiner G Ulrich and Wolfgang Baumgaertner and Ingo Gerhauser and Frank Seeliger and Verena Haist and Ulrich Deschl and Susanne Alldinger},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 8},
  pages={783-93}
}
Theiler murine encephalomyelitis (TME) represents a highly relevant viral model for multiple sclerosis. Matrix metalloproteinases (MMPs) degrade extracellular matrix molecules and are involved in demyelination processes. To elucidate their impact on demyelination in TME, spinal cords of TME virus (TMEV)-infected SJL/J mice were taken at 9 different time points postinfection (pi) ranging from 1 hour to 196 days pi and investigated for the expression of TMEV, MMP-2, -3, -7, -9, -10, -11, -12, -13… CONTINUE READING