MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.

@article{Gill2004MMP10IO,
  title={MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.},
  author={J. Gill and Ian G Kirwan and J. Seargent and S. Martin and S. Tijani and V. Anikin and A. Mearns and M. Bibby and A. Anthoney and P. Loadman},
  journal={Neoplasia},
  year={2004},
  volume={6 6},
  pages={
          777-85
        }
}
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type to address the relationship between MMP-10 and tumor characteristics and to evaluate MMP-10 as a therapeutic target in non small cell lung carcinoma (NSCLC). Unlike the majority of MMPs, MMP-10 was located in the tumor mass as opposed to tumor stroma… Expand
Expression of MMP-10 in lung cancer.
Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis
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