MMP-1 and MMP-2 in the cervix uteri in different steps of malignant transformation--an immunohistochemical study.

@article{Brummer2002MMP1AM,
  title={MMP-1 and MMP-2 in the cervix uteri in different steps of malignant transformation--an immunohistochemical study.},
  author={Oliver Brummer and Gerd Boehmer and Bettina Hollwitz and Peer Flemming and K Ulrich Petry and Henning K{\"u}hnle},
  journal={Gynecologic oncology},
  year={2002},
  volume={84 2},
  pages={222-7}
}
OBJECTIVES Enzymatic degradation of the extracellular matrix (ECM) represents a key element in the multistage process of tumor invasion and metastasis. This process requires extensive degradation of ECM components such as basement membrane collagen (type IV) and interstitial collagen (type I, II, III). Matrix metalloproteinase-2 (MMP-2) specifically cleaves collagen type IV, the major collagen of the basement membrane. MMP-1 digests interstitial collagen type I and III, the main collagen types… CONTINUE READING

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