MMP-1-PAR1 axis mediates LPA-induced epithelial ovarian cancer (EOC) invasion.

  title={MMP-1-PAR1 axis mediates LPA-induced epithelial ovarian cancer (EOC) invasion.},
  author={Feng-qiang Wang and J. Fisher and David A. Fishman},
  journal={Gynecologic oncology},
  volume={120 2},
OBJECTIVES MMP-1 is over-expressed in many cancers, with high expression often associated with poor survival. In the present study, we examined the expression of MMP-1 in EOC and its role in EOC invasion. Moreover, we evaluated the role of a newly identified MMP-1-protease activated receptor (PAR)-1 axis in LPA-induced EOC invasion. METHODS MMP-1 and PAR1 mRNA expression in EOC cell lines was determined by real time PCR. MMP-1 mRNA expression in 96 normal and carcinoma ovarian tissue… CONTINUE READING

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