MMP-1, IL-1β, and COX-2 mRNA Expression is Modulated by Static Load in Rabbit Flexor Tendons

@article{Asundi2007MMP1IA,
  title={MMP-1, IL-1β, and COX-2 mRNA Expression is Modulated by Static Load in Rabbit Flexor Tendons},
  author={Krishna R. Asundi and David M. Rempel},
  journal={Annals of Biomedical Engineering},
  year={2007},
  volume={36},
  pages={237-243}
}
Tendon cells respond to their mechanical environment by synthesizing and degrading the surrounding matrix. This study examined how expression of genes associated with tendon degeneration is affected by static loads. Forty flexor tendons from 10 New Zealand White rabbits were harvested and secured in a tissue loading system. A static load of 0, 2, 4, or 6 MPa was applied to tendons for 20 h. MMP-1, IL-1β, COX-2, GAPDH, and 18s mRNA expression was measured by qRT-PCR. MMP-1 expression in tendons… CONTINUE READING

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Arnoczky . In vitro alterations in cytoskeletal tensional homeostasis control gene expression in tendon cells

  • M. Lavagnino, P. S.
  • J . Orthop . Res .
  • 2007

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