MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.

@article{McVey2008MMEJRO,
  title={MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings.},
  author={Mitch McVey and Sang Eun Lee},
  journal={Trends in genetics : TIG},
  year={2008},
  volume={24 11},
  pages={529-38}
}
DNA double-strand breaks are normal consequences of cell division and differentiation and must be repaired faithfully to maintain genome stability. Two mechanistically distinct pathways are known to efficiently repair double-strand breaks: homologous recombination and Ku-dependent non-homologous end joining. Recently, a third, less characterized repair mechanism, named microhomology-mediated end joining (MMEJ), has received increasing attention. MMEJ repairs DNA breaks via the use of… CONTINUE READING
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