MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.

  title={MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.},
  author={Massimo Pizzato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 20},
Optimal infectivity of HIV-1 virions requires synthesis of the HIV-1 regulatory protein Nef in some producer cells but not others. A survey of 18 lymphoid cell lines found that Nef was dispensable in three, each of which harbored gammaretroviruses. Nef-dependent cell lines were rendered Nef-independent by a cell-free supernatant from the independent lines or by transfection of cloned murine leukemia virus (MLV). Analysis of MLV deletion mutations identified glycosylated gag (glycogag) as the… CONTINUE READING

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Mutation in the glycosylated gag protein of murine leukemia virus results in reduced in vivo infectivity and a novel defect in viral budding or release

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