MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells

  title={MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells},
  author={Lucy Q. Liu and Nicolas Gaboriaud and Konstantina Vougogianopoulou and Yan Tian and Jun Wu and Wei Wen and Leandros A. Skaltsounis and Richard Jove},
  journal={Cancer Biology \& Therapy},
  pages={178 - 184}
Janus kinase (JAK) and Src kinase are the two major tyrosine kinase families upstream of signal transducer and activator of transcription (STAT). Among the seven STAT family proteins, STAT3 is constitutively activated in many diverse cancers. Upon activation, JAK and Src kinases phosphorylate STAT3, and thereby promote cell growth and survival. MLS-2384 is a novel 6-bromoindirubin derivative with a bromo-group at the 6-position on one indole ring and a hydrophilic group at the 3′-position on… 

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