MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.

@article{Zhang2002MLN64MM,
  title={MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.},
  author={Mei Zhang and Pei I. Liu and Nancy K. Dwyer and Lane K. Christenson and Toshio Fujimoto and F. Mart{\'i}nez and Marcy Comly and John A Hanover and E. Joan Blanchette-Mackie and Jerome F Strauss},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 36},
  pages={
          33300-10
        }
}
This study demonstrates that the steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing protein, MLN64, participates in intracellular cholesterol trafficking. Analysis of the intracellular itinerary of MLN64 and MLN64 mutants tagged with green fluorescent protein showed that the N-terminal transmembrane domains mediate endocytosis of MLN64 from the plasma membrane to late endocytic compartments. MLN64 constitutively traffics via dynamic NPC1-containing late… CONTINUE READING

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