MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.

@article{Vallet2007MLN3897AN,
  title={MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.},
  author={Sonia Vallet and Noopur Raje and Kenji Ishitsuka and Teru Hideshima and Klaus Podar and Shweta Chhetri and Samantha Pozzi and Iris Breitkreutz and Tanyel Kiziltepe and Hiroshi Yasui and Enrique Mar{\'i}a Ocio and Norihiko Shiraishi and Janice Jin and Yutaka Okawa and Hiroshi Ikeda and Siddhartha Mukherjee and Nileshwari Vaghela and Diana Cirstea and Marco Ladetto and Mario Boccadoro and Kenneth C. Anderson},
  journal={Blood},
  year={2007},
  volume={110 10},
  pages={3744-52}
}
The interaction between osteoclasts (OCs) and multiple myeloma (MM) cells plays a key role in the pathogenesis of MM-related osteolytic bone disease (OBD). MM cells promote OC formation and, in turn, OCs enhance MM cell proliferation. Chemokines are mediators of MM effects on bone and vice versa; in particular, CCL3 enhances OC formation and promotes MM cell migration and survival. Here, we characterize the effects of MLN3897, a novel specific antagonist of the chemokine receptor CCR1, on both… CONTINUE READING

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