MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling

Abstract

Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for cancer initiation, progression, invasion, and motility of carcinoma cells. We showed that AF1q is associated with STAT3 signaling in breast cancer cells. In xenograft models, enhanced AF1q expression activated STAT3 and promoted tumor… (More)
DOI: 10.18632/oncotarget.9759

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Cite this paper

@inproceedings{Park2016MLLT11AF1qBO, title={MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling}, author={Jino Park and Soojin Kim and Joongho Joh and Scot C. Remick and Donald M. Miller and Jun Yan and Zeyad Kanaan and J Chao and Maxwell M. Krem and Soumit K. Basu and Shotaro Hagiwara and Lukas Kenner and Richard Moriggl and Kevin D. Bunting and William W. Tse}, booktitle={Oncotarget}, year={2016} }