MLL5 contributes to hematopoietic stem cell fitness and homeostasis.

  title={MLL5 contributes to hematopoietic stem cell fitness and homeostasis.},
  author={Yan Zhang and Jasmine W. S. Wong and Mark Klinger and Mary T Tran and Kevin M. Shannon and Nigel Killeen},
  volume={113 7},
MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid malignancy. Here we show that inactivation of the Mll5 gene in mice results in a 30% reduction in the average representation of hematopoietic stem cells and in functional impairment of long-term hematopoietic repopulation potential under competitive conditions. Bone marrow cells from Mll5-deficient mice were defective in… CONTINUE READING
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