MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.

@article{Wu2020MLL3IB,
  title={MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.},
  author={Han-Tsang Wu and Yi-En Liu and Kai-Wen Hsu and Yu-fen Wang and Ya-chi Chan and Yeh Chen and D. Chen},
  journal={The American journal of Chinese medicine},
  year={2020},
  volume={48 5},
  pages={
          1221-1241
        }
}
Tamoxifen is one of the most common hormone therapy drug for estrogen receptor (ER)-positive breast cancer. Tumor cells with drug resistance often cause recurrence and metastasis in cancer patients. Luteolin is a natural compound found from various types of vegetables and exhibit anticancer activity in different cancers. This study demonstrated that luteolin inhibits the proliferation and induces apoptosis of tamoxifen-resistant ER-positive breast cancer cells. Luteolin also causes cell cycle… Expand
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