MLL1 is essential for the senescence-associated secretory phenotype.

  title={MLL1 is essential for the senescence-associated secretory phenotype.},
  author={Brian C. Capell and Adam M. Drake and Jiajun Zhu and Parisha P. Shah and Zhixun Dou and Jean A. Dorsey and Daniel F. Simola and Greg Donahue and Morgan A. Sammons and Taranjit Singh Rai and Christopher A Natale and Todd W Ridky and Peter David Adams and Shelley L Berger},
  journal={Genes & development},
  volume={30 3},
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP). Previous observations link the transcription-associated methyltransferase and oncoprotein MLL1 to the DDR, leading us to investigate the role of MLL1… CONTINUE READING
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