MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

@article{Buechele2015MLLLI,
  title={MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.},
  author={Corina Buechele and Erin H. Breese and Dominik Schneidawind and Chiou-Hong Lin and Johan Jeong and Jes{\'u}s Duque-Afonso and Stephen Hon Kit Wong and Kevin S. Smith and Robert S. Negrin and Matthew H Porteus and Michael L. Cleary},
  journal={Blood},
  year={2015},
  volume={126 14},
  pages={1683-94}
}
Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and treatment-related leukemias and confer a poor prognosis. Studies based primarily on mouse models have substantially advanced our understanding of MLL leukemia pathogenesis, but often use supraphysiological oncogene expression with uncertain implications for human leukemia. Genome editing using site-specific nucleases provides a powerful new technology for gene modification to potentially model human… CONTINUE READING
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