MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.

@article{Deng2004MLL5P,
  title={MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.},
  author={L Deng and Isaac Chiu and Jack Leonard Strominger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 3},
  pages={757-62}
}
MLL5 is a mammalian trithorax group (trx-G) gene identified within chromosome band 7q22, a frequently deleted element found in cytogenetic aberrations of acute myeloid malignancies. MLL5 cDNA was linked with the FLAG and V5 tags at the N and C terminus, respectively, and transfected into 293T cells. Immunofluoresence staining of the expressed tagged MLL5 protein showed localization to the nucleus and exclusion from nucleoli, and no surface staining was detected. Both ectopically introduced and… CONTINUE READING

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