MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.


Reactive oxygen species (ROS) influence diverse cellular processes, including proliferation and apoptosis. Both endogenous and exogenous ROS activate signaling through mitogen-activated proteins kinase (MAPK) pathways, including those involving extracellular signal-regulated kinases (ERKs) or c-Jun N-terminal kinases (JNKs). Whereas low concentrations of… (More)
DOI: 10.1126/scisignal.2005260


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