MLK3 Is Part of a Feedback Mechanism That Regulates Different Cellular Responses to Reactive Oxygen Species

@article{Lee2014MLK3IP,
  title={MLK3 Is Part of a Feedback Mechanism That Regulates Different Cellular Responses to Reactive Oxygen Species},
  author={Ho-Sung Lee and Chae Young Hwang and Sung-Young Shin and K Kwon and Kwang-Hyun Cho},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra52-ra52}
}
Reactive oxygen species (ROS) influence diverse cellular processes, including proliferation and apoptosis. Both endogenous and exogenous ROS activate signaling through mitogen-activated proteins kinase (MAPK) pathways, including those involving extracellular signal–regulated kinases (ERKs) or c-Jun N-terminal kinases (JNKs). Whereas low concentrations of ROS generally stimulate proliferation, high concentrations result in cell death. We found that low concentrations of ROS induced activating… CONTINUE READING
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