MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

@inproceedings{Savio2012MLH1RP,
  title={MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals},
  author={Andrea J. Savio and Mathieu Lemire and Miralem Mrkonjic and Steven Gallinger and Brent W. Zanke and Thomas J. Hudson and Bharati Bapat},
  booktitle={PloS one},
  year={2012}
}
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between… CONTINUE READING

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References

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Distinct DNA methylomes of newborns and centenarians.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 1 Excerpt

Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2012
View 1 Excerpt

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