MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients.

@article{Wandt2008MLDAT,
  title={MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients.},
  author={Hannes Wandt and Ulrike Sch{\"a}kel and Frank P. Kroschinsky and Gabriele Prange-Krex and B. Mohr and Christian Thiede and Ulrich Pascheberg and Silke Soucek and Markus Schaich and Gerhard Ehninger},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={1855-61}
}
Between February 1996 and December 2004, the German Leukemia Study Initiative registered 1766 consecutive patients for the acute myeloid leukemia (AML) 96 study, all of whom were diagnosed by central cytomorphology according to the French-American-British (FAB) and the new World Health Organization (WHO) classification. We focused our analysis on the prognostic impact of multilineage dysplasia (MLD) as a new parameter of the WHO classification for AML. We could not confirm the WHO statement… CONTINUE READING