MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination.

@article{Leitman2011MLCKRS,
  title={MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination.},
  author={Ellen M Leitman and Ambika Tewari and Meryl E. Horn and Mateusz Urbanski and Evangelos Damanakis and Steven Einheber and James L. Salzer and Primal de Lanerolle and Carmen V. Melendez-Vasquez},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 22},
  pages={3784-96}
}
Signaling through cyclic AMP (cAMP) has been implicated in the regulation of Schwann cell (SC) proliferation and differentiation. In quiescent SCs, elevation of cAMP promotes the expression of proteins associated with myelination such as Krox-20 and P0, and downregulation of markers associated with the non-myelinating SC phenotype. We have previously shown… CONTINUE READING