MLC1: a novel protein in distal astroglial processes.

  title={MLC1: a novel protein in distal astroglial processes.},
  author={Peter Boor and Koen E de Groot and Quinten Waisfisz and Wouter Kamphorst and Cees B. M. Oudejans and J Michael Powers and Jan C. Pronk and Gert C. Scheper and Marjo S. van der Knaap},
  journal={Journal of neuropathology and experimental neurology},
  volume={64 5},
Megaloencephalic leukoencephalopathy with subcortical cysts (MLC) is a progressive cerebral white matter disease in children caused by mutations in the MLC1 gene. This disease is histopathologically characterized by myelin splitting and intramyelinic vacuole formation. MLC1 encodes a novel protein, MLC1, which is mainly expressed in the brain and leukocytes. The function is unknown, although a transport function has been suggested. In this article, we provide experimental data addressing the… CONTINUE READING


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