ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

@inproceedings{Youngsaye2013ML212AS,
  title={ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans
},
  author={Willmen Youngsaye and Cathy L. Hartland and Barbara J Morgan and Amal Ting and Partha P. Nag and Benjamin Matteson Vincent and Carrie A Mosher and Joshua A. Bittker and Sivaraman Dandapani and Michelle A. J. Palmer and Luke Whitesell and Susan L. Lindquist and Stuart L. Schreiber and B. Quintanilla Mu{\~n}oz},
  booktitle={Beilstein journal of organic chemistry},
  year={2013}
}
The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure… CONTINUE READING