MKRN1: Uncovering function by an unbiased systems approach

@article{Carpenedo2016MKRN1UF,
  title={MKRN1: Uncovering function by an unbiased systems approach},
  author={Richard L. Carpenedo and Paul A. Cassar and William L. Stanford},
  journal={Cell Cycle},
  year={2016},
  volume={15},
  pages={303 - 304}
}
Gene regulatory networks (GRNs) integrate intrinsic and extrinsic signals to maintain cell identity, homeostasis and function. In stem cells, network models have been drafted to describe the molecular underpinnings of self-renewal and differentiation.1 However, previous studies in this area have proven to be transcription factor-centric, while molecular functions other than DNA binding and direct regulation of transcription have been largely overlooked.2 Recently, we described an integrative… 
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Makorin 1 controls embryonic patterning by alleviating Bruno-mediated repression of oskar translation
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It is demonstrated that Mkrn1 interacts with poly(A) binding protein (pAbp) and binds osk 3’ UTR in a region adjacent to A-rich sequences and overlaps with Bruno (Bru) responsive elements (BREs), which regulate osk translation.
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Systems‐level analyses support a role for the E3 ligase MKRN1 as a ribonucleoprotein within the ESC GRN, although MK RN1 is not required for stress granule formation, or survival of unstressed ESCs.
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The seminal genomic studies that have shaped the understanding of the ESC GRN are highlighted and alternate post‐transcriptional gene regulatory mechanisms that require in depth analyses to draft networks that fully model ESC behavior are described.
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