MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1.

@article{Yu2011MKP1RC,
  title={MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1.},
  author={Hong Yu and Yuhao Sun and Courtney J. Haycraft and Viswanathan Palanisamy and Keith Lough Kirkwood},
  journal={Cytokine},
  year={2011},
  volume={56 2},
  pages={
          245-55
        }
}
MAPK phosphatase-1 (MKP-1)/dual specificity protein phosphatase-1 (DUSP-1) is a negative regulator of the host inflammatory response to infection. However, the mechanisms underlying the regulation of cytokine expression by MKP-1, especially at the post-transcriptional level, have not been fully delineated. In the current study, MKP-1 specifically dephosphorylated activated MAPK responses and attenuated LPS-induced IL-6, IL-10, and TNF-α expression. In addition, MKP-1 was important in… CONTINUE READING
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