MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

@article{Yu2017MKL1DT,
  title={MKL1 defines the H3K4Me3 landscape for NF-$\kappa$B dependent inflammatory response},
  author={Liming Yu and Fei Fang and X. Dai and H. Xu and Xiaohong Qi and M. Fang and Y. Xu},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Macrophage-dependent inflammatory response is considered a pivotal biological process that contributes to a host of diseases when aberrantly activated. The underlying epigenetic mechanism is not completely understood. We report here that MKL1 was both sufficient and necessary for p65-dependent pro-inflammatory transcriptional program in immortalized macrophages, in primary human and mouse macrophages, and in an animal model of systemic inflammation (endotoxic shock). Extensive chromatin… Expand
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