MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells


Mounting evidence suggests that lipoxygenase (LO)-catalyzed products may play a key role in the development and progression of human cancers. In this study, we analyzed the effects of a 5-LO inhibitor, which inhibits the conversion of arachidonic acid to leukotrienes, on cell proliferation and apoptosis in human malignant glioma cells, including 5-LO… (More)
DOI: 10.1007/s11060-009-0036-9


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