MK801 influences L-DOPA-induced dopamine release in intact and hemi-parkinson rats.

@article{Jonkers2000MK801IL,
  title={MK801 influences L-DOPA-induced dopamine release in intact and hemi-parkinson rats.},
  author={Nadine Jonkers and Sophie Sarre and Guy Ebinger and Yvette Michotte},
  journal={European journal of pharmacology},
  year={2000},
  volume={407 3},
  pages={281-91}
}
In vivo microdialysis was used to investigate the influence of dizocilpine (MK801) on basal and levodopa (L-DOPA)-induced extracellular dopamine levels in striatum and substantia nigra of intact and 6-hydroxydopamine-lesioned rats. In lesioned rats, extracellular dopamine was decreased in striatum but not in substantia nigra. L-DOPA (25 mg/kg i.p. after… CONTINUE READING