MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain.

@article{Olney1989MK801PH,
  title={MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain.},
  author={John W. Olney and C Ikonomidou and Judith L. Mosinger and Gregory E Frierdich},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 5},
  pages={1701-4}
}
Recent evidence implicates the endogenous excitatory amino acids, glutamate (Glu) and aspartate, in hypoxic/ischemic neuronal degeneration. In a preceding article (Ikonomidou et al., 1989) we described a new model for studying hypoxic/ischemic neuronal degeneration in the infant rat brain that entails unilateral common carotid artery ligation followed by exposure to a partial vacuum for 75 min. Promising features of this model include a low mortality rate and high incidence of acute brain… CONTINUE READING