MK-801 prevents chemical kindling induced by pentylenetetrazol in rats.

@article{Giorgi1991MK801PC,
  title={MK-801 prevents chemical kindling induced by pentylenetetrazol in rats.},
  author={Osvaldo Giorgi and Marzia Orlandi and Daniele Lecca and Maria Giuseppa Corda},
  journal={European journal of pharmacology},
  year={1991},
  volume={193 3},
  pages={
          363-5
        }
}
  • Osvaldo Giorgi, Marzia Orlandi, +1 author Maria Giuseppa Corda
  • Published in
    European journal of…
    1991
  • Chemistry, Medicine
  • The repeated administration of pentylenetetrazol (PTZ) at a subconvulsant dose (30 mg/kg i.p., three times a week for nine weeks) produced kindling in 90% of rats under treatment. Pretreatment with the N-methyl-D-aspartate receptor antagonist, MK-801 (1 mg/kg i.p., 40 min before PTZ), prevented the behavioral manifestation (i.e. motor seizures) as well as the development of kindling. In fact, convulsions were not observed in rats pretreated with MK-801 either during the chronic PTZ… CONTINUE READING

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