MK-801 potentiates ethanol's effects on locomotor activity in mice.

  title={MK-801 potentiates ethanol's effects on locomotor activity in mice.},
  author={Elaine H. Shen and Tamara J Phillips},
  journal={Pharmacology, biochemistry, and behavior},
  volume={59 1},
FAST vs. SLOW selected mouse lines and C57BL/6J (B6) vs. DBA/2J (D2) inbred strains differ in their sensitivities to ethanol's locomotor stimulant effects, and provide two unique sets of genetic animal models to study neurophysiological substrates of this behavior. To determine whether NMDA receptor function mediates sensitivity to ethanol's stimulant effects, we assessed the effects of the noncompetitive NMDA antagonist, MK-801, on locomotor activity of naive and ethanol-treated FAST, SLOW, B6… CONTINUE READING

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