MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning.

  title={MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning.},
  author={Steven Harrod and Robert W. Flint and David C. Riccio},
  journal={Pharmacology, biochemistry, and behavior},
  volume={69 3-4},
Two experiments using a state-dependent retention (SDR) design determined whether MK-801 blocked the acquisition and retention of an avoidance response. In Experiments 1 and 2, rats were trained and tested 30 min after injections of either saline or MK-801 (0.05 and 0.10 mg/kg, respectively). Two minutes after training, subjects were immediately tested, and in both experiments, the avoidance response was acquired. The 24-h retention tests for Experiment 1 revealed that the data marginally… CONTINUE READING

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