MK-801 changes the role of glutamic acid on modulation of algesia in nucleus accumbens.

@article{Shi2010MK801CT,
  title={MK-801 changes the role of glutamic acid on modulation of algesia in nucleus accumbens.},
  author={Tie-feng Shi and Chun-xiao Yang and Dong-xiao Yang and Run-sheng Jiao and Guang-wen Zhang and He-ren Gao and Duo Zhang and Man-ying Xu},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={395 3},
  pages={
          407-11
        }
}
Dizocilpine maleate (MK-801) causes the blockage of the glutamic acid (Glu) receptors in the central nervous system that are involved in pain transmission. However, the mechanism of action of MK-801 in pain-related neurons is not clear, and it is still unknown whether Glu is involved in the modulation of this processing. This study examines the effect of MK-801, Glu on the pain-evoked response of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the nucleus accumbens (NAc) of… Expand
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