MK-801, an excitatory amino acid antagonist, does not improve neurologic outcome following cardiac arrest in cats.

@article{Fleischer1989MK801AE,
  title={MK-801, an excitatory amino acid antagonist, does not improve neurologic outcome following cardiac arrest in cats.},
  author={Jennifer Fleischer and Akio Tateishi and John Drummond and Mark S. Scheller and Marjorie R. Grafe and Mark H. Zornow and Gary T. Shearman and Heather M Shapiro},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1989},
  volume={9 6},
  pages={795-804}
}
The excitatory amino antagonist MK-801 was administered to cats following resuscitation from cardiac arrest to evaluate its effect on neurologic and neuropathologic outcome in a clinically relevant model of complete cerebral ischemia. In 29 cats studied, cardiac arrest (ventricular fibrillation) was maintained for 18 min and resuscitation was successfully performed in 21 cats. Four animals underwent a sham arrest. MK-801 or placebo was administered in a blinded, randomized manner. Beginning at… CONTINUE READING

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