MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.

@article{Shimomura2010MK5108AH,
  title={MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.},
  author={Toshiyasu Shimomura and Shinichi Hasako and Yoko Nakatsuru and Takashi Mita and Koji Ichikawa and Tsutomu Kodera and Takumi Sakai and Tadahiro Nambu and Mayu Miyamoto and Ikuko S. Takahashi and Satomi Miki and Nobuhiko Kawanishi and Mitsuru Ohkubo and Hidehito Kotani and Yoshikazu Iwasawa},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 1},
  pages={157-66}
}
Aurora-A kinase is a one of the key regulators during mitosis progression. Aurora-A kinase is a potential target for anticancer therapies because overexpression of Aurora-A, which is frequently observed in some human cancers, results in aberrant mitosis leading to chromosomal instability and possibly tumorigenesis. MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Although most of the Aurora-kinase inhibitors target both Aurora-A and Aurora-B, MK-5108… CONTINUE READING

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Antitumor activity of Mol Cancer Ther

  • MG Manfredi, JA Ecsedy, KA Meetze
  • Published OnlineFirst January
  • 2010
2 Excerpts

The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule stabilizing agents in a colon carcinoma model

  • EC VanderPorten, P Taverna, JN Hogan
  • Mol Cancer Ther 2009;8:930–9
  • 2009
1 Excerpt

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