MK-386, an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen.

@article{Schwartz1997MK386AI,
  title={MK-386, an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen.},
  author={Jules I. Schwartz and Wesley Kiyoshi Tanaka and Deng-hong Wang and David L. Ebel and Lori A. Geissler and Aimee L Dallob and Barry Hafkin and Barry J. Gertz},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 5},
  pages={
          1373-7
        }
}
Two isozymes (types 1 and 2) of 5alpha-reductase (5alphaR; EC 1.3.99.5), with differential tissue distribution, catalyze the reduction of testosterone (T) to dihydrotestosterone (DHT) in humans. This study examined sequentially increasing oral doses of MK-386 (4,7beta-dimethyl-4-aza-5alpha-cholestan-3-one), an azasteroid that specifically inhibits the human 5alphaR1 isozyme in vitro. Finasteride, a selective inhibitor of 5alphaR2, was included for comparison. One hundred men were evaluated in a… CONTINUE READING
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