MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.

@article{King1989MK212IR,
  title={MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.},
  author={Bryan H. King and C Brazell and Colin Trevor Dourish and Derek N. Middlemiss},
  journal={Neuroscience letters},
  year={1989},
  volume={105 1-2},
  pages={174-6}
}
The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked by the 5-HT1C antagonists mesulergine and metergoline but not by spiperone, ketanserin, or (-)-pindolol. The results suggest that MK-212 activates the 5-HT1C receptor subtype to increase ACTH. 

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