MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.

@article{Doebber2004MK0767AN,
  title={MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.},
  author={Thomas W. Doebber and Linda J. Kelly and Gaochao Zhou and Roger D Meurer and Chhabi Biswas and Ying Li and Margaret S. Wu and Marc C Ippolito and Yu-sheng Chao and Pei-ran Wang and Samuel D. Wright and David Moller and Joel P. Berger},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 2},
  pages={323-8}
}
Here, we characterize the actions of MK-0767, a dual ligand of the nuclear receptors peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma. In cell-based assays, MK-0767 produced potent activation of human PPARgamma and PPARalpha with a gamma:alpha potency ratio of approximately 2. The dual agonist induced high affinity interactions of PPARalpha and PPARgamma with the transcriptional coactivator CBP in vitro. In ob/ob mice, MK-0767 normalized hyperglycemia and hyperinsulinemia… CONTINUE READING

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