MITOMAP: a human mitochondrial genome database--1998 update

@article{Kogelnik1998MITOMAPAH,
  title={MITOMAP: a human mitochondrial genome database--1998 update},
  author={Andreas M. Kogelnik and Marie T. Lott and Michael D. Brown and Shamkant B. Navathe and Douglas C. Wallace},
  journal={Nucleic acids research},
  year={1998},
  volume={26 1},
  pages={
          112-5
        }
}
We have continued to develop MITOMAP (http://www.gen.emory. edu/MITOMAP ), a comprehensive database for the human mitochondrial DNA (mtDNA). MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations and their clinical characteristics, population associated variation, and gene-gene interactions. Over the past year we have increased the degree of interlinking of MITOMAP information available on… 
View on PubMed
europepmc.org
79 Citations
Highly Influential Citations
3
Background Citations
32
Methods Citations
3

Figures and Tables from this paper

79 Citations

MITOMAP: a human mitochondrial genome database—2004 update

System administrative changes have been made to improve security and efficiency, and to make MITOMAP compatible with a new automatic mtDNA sequence analyzer known as Mitomaster.

MitoP2, an integrated database on mitochondrial proteins in yeast and man

An annotated reference set of mitochondrial proteins of yeast and human proteins is created based on the current literature and lends itself to the genetic characterization of human mitochondriopathies.

Computational identification of human mitochondrial proteins based on homology to yeast mitochondrially targeted proteins

A novel dataset of human nuclear-encoded mitochondrial proteins is produced using the web-based computer program Mitoprot to predict which proteins in the Saccharomyces cerevisiae genome are targeted to mitochondria and identifies the homology to all S.cerevisiae mitochondrially targeted proteins.

The Mitochondrial Genome and Human Mitochondrial Diseases

Since both neutral and mildly pathogenic mutations of mtDNA are progressively accumulated in maternal phyletic lines, molecular analysis of these mutations permits not only reconstruction of the genealogical tree of modern humans, but also estimation of the role that these mutations play in natural selection.

MOUSE (Mitochondrial and Other Useful SEquences) a compilation of population genetic markers

MOUSE is an integrated and comprehensive compilation of mtDNA from hypervariable regions I and II and of the low recombining nuclear loci Xq13.3 from about 11 200 humans and great apes, whose geographic and if applicable, linguistic classification is stored with their aligned sequences and publication details.

A compositional segmentation of the human mitochondrial genome is related to heterogeneities in the guanine mutation rate.

A comparison to two independent databases of mitochondrial mutations and polymorphisms showed that the high substitution rate of guanine in human mtDNA is largest in the category 3 segments, suggesting that this heterogeneity in the mutation rate is partly independent of respiratory chain function and is a direct property of the genome sequence itself.

MtDNA: The small workhorse of evolutionary studies.

The future of mitochondrial DNA is examined as a useful tool in studies centered around evolution because of its small size in animals, the technical ease of manipulating mitochondrial genome and the dynamics of its evolutionary change.

Human mitochondrial tRNAs in health and disease

Emerging fundamental knowledge on the structure/function relationships of these particular tRNAs and an overview of the large variety of mechanisms within translation, affected by mutations are summarized.

Molecular Investigations on tRNAs Involved in Human Mitochondrial Disorders

Initial results obtained by comparative mitochondrial proteomics turn out to be very promising for deciphering unexpected molecular partners involved in the pathological status of the mitochondria.

Human mitochondrial transfer RNAs: Role of pathogenic mutation in disease

A scoring system is used to determine the pathogenicity of the mutations and an overview of a large variety of mechanisms by which mutations may affect the mitochondrial translation machinery and cause disease is provided.
...

References

SHOWING 1-7 OF 7 REFERENCES

In Cuticchia.A.J. (ed.), Human Gene Mapping 1995: A Compendium

  • 1995

Annu. Rev. Biochem

  • Annu. Rev. Biochem
  • 1992

Human Gene Mapping 1995: A Compendium

  • Human Gene Mapping 1995: A Compendium
  • 1995

Nucleic Acids Res

  • Nucleic Acids Res
  • 1994

Nucleic Acids Res

  • Nucleic Acids Res
  • 1996

Am. J. Hum. Genet

  • Am. J. Hum. Genet
  • 1995

Nucleic Acids Res. Nucleic Acids Res

  • Nucleic Acids Res. Nucleic Acids Res
  • 1996