MITOMAP: a human mitochondrial genome database--1998 update

@article{Kogelnik1998MITOMAPAH,
  title={MITOMAP: a human mitochondrial genome database--1998 update},
  author={Andreas M. Kogelnik and Marie T. Lott and Michael D. Brown and Shamkant B. Navathe and Douglas C. Wallace},
  journal={Nucleic acids research},
  year={1998},
  volume={26 1},
  pages={
          112-5
        }
}
We have continued to develop MITOMAP (http://www.gen.emory. edu/MITOMAP ), a comprehensive database for the human mitochondrial DNA (mtDNA). MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations and their clinical characteristics, population associated variation, and gene-gene interactions. Over the past year we have increased the degree of interlinking of MITOMAP information available on… 

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References

SHOWING 1-7 OF 7 REFERENCES

In Cuticchia.A.J. (ed.), Human Gene Mapping 1995: A Compendium

  • 1995

Annu. Rev. Biochem

  • Annu. Rev. Biochem
  • 1992

Human Gene Mapping 1995: A Compendium

  • Human Gene Mapping 1995: A Compendium
  • 1995

Nucleic Acids Res

  • Nucleic Acids Res
  • 1994

Nucleic Acids Res

  • Nucleic Acids Res
  • 1996

Am. J. Hum. Genet

  • Am. J. Hum. Genet
  • 1995

Nucleic Acids Res. Nucleic Acids Res

  • Nucleic Acids Res. Nucleic Acids Res
  • 1996